Relationship between ionized calcium and serum albumin level in children with idiopathic nephrotic syndrome

  • Viiola Irene Winata Department of Child Health, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin General Hospital, Bandung, West Java
  • Dida Akhmad Gurnida Department of Child Health, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin General Hospital, Bandung, West Java
  • Nanan Sekarwana Department of Child Health, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin General Hospital, Bandung, West Java
DOI: https://doi.org/10.14238/pi50.6.2010.361-4
Keywords: nephrotic syndrome, ionized calcium, serum albumin

Abstract

Background Nephrotic syndrome (NS) patients frequently have abnormalities in calcium metabolism that manifest as hypocalcemia and reduced intestinal absorption of calcium. Hypocalcemia is initially attributed to hypoalbuminemia but it may also relate to a low level of ionized calcium. The ionized calcium level depends on the severity and duration of proteinuria.

Objective To assess the rel ationship between ionized calcium and serum albumin level in idiopathic NS children.

Methods An analytical study with cross-sectional design was applied to NS and healthy children between 1-14 years old in the Child Health Department of Hasan Sadikin Hospital, Bandung from December 2009 to April 2010. Ionized calcium was examined by Ca2 + analyzer AVL 980 with ion-selective electrodes (ISE) methods.

Results A total of34 subjects were recruited, consist of 17 NS and 17 healthy children. The mean ionized calcium and serum albumin level in NS children was 4.56 (SD 0.23) mg/dLand 1.45 (SD 0.24) g/dL, respectively. Statistical difference between ionized calcium level in NS and in healthy children was significant (P<0.05). Pearson correlation test between ionized calcium and serum albumin was significant (P<0.05) with correlation coefficient (r) 0.53. We found the following equation to estimate ionized calcium (y) based on the serum albumin level (x): y=3.84+0.49x.

Conclusion There is a moderately positive linear relationship between ionized calcium and serum albumin level in NS children.

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Published
2016-10-26
How to Cite
1.
Winata V, Gurnida D, Sekarwana N. Relationship between ionized calcium and serum albumin level in children with idiopathic nephrotic syndrome. PI [Internet]. 26Oct.2016 [cited 5May2024];50(6):361-. Available from: https://www.paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/991
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Vol 50 No 6 (2010): November 2010
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Received 2016-10-26
Accepted 2016-10-26
Published 2016-10-26