Association between low-grade chronic inflammation with adipocytokines and body fat mass in superobese male children

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Aryono Hendarto
Sudigdo Sastroasmoro
Damayanti Rusli Sjarif


Background Obesity causes adipocytokines dysregulation and enhances the pro-inflammatory response. Low-grade chronic inflammation is related to cardiometabolic diseases.

Objective To evaluate the status of low-grade chronic inflammation in pre-pubertal, obese boys and its potential correlation to adipocytokines and body fat mass.

Methods This cross-sectional study included pre-pubertal, male, superobese children as the subjects. We determined obesity status using the CDC 2000 BMI-for-age chart. Body fat percentage was measured using bioelectric impedance analysis (BIA). Fasting blood specimens were collected to evaluate hsCRP, leptin, adiponectin, and TNF-α levels.

Results Eighty subjects were recruited into this study, with a mean age of 6.9 years. Ten subjects (12.5%) had low-grade chronic inflammation (hsCRP level ≥ 1 mg/L). The levels of hsCRP was not correlated with leptin, adiponectin, and TNF-α levels. A weak, but significant correlation was observed between hsCRP level and body fat mass (r= +0.383; P<0.0001). The hsCRP level increased with increasing body fat mass, until it reached its peak at body fat mass of 28 kg. Beyond that point, hsCRP level was stable.

Conclusion Low-grade chronic inflammation begins at a young age in obese children. The hsCRP level has a weak correlation with body fat mass, but no correlation with adipocytokine levels. Prevention and treatment of childhood obesity should be prioritized to prevent further cardiovascular and metabolic diseases.

Article Details

How to Cite
Hendarto A, Sastroasmoro S, Sjarif D. Association between low-grade chronic inflammation with adipocytokines and body fat mass in superobese male children. PI [Internet]. 18Feb.2019 [cited 23Apr.2021];59(1):13-. Available from:
Pediatric Nutrition & Metabolic Disease
Received 2018-12-27
Accepted 2019-02-18
Published 2019-02-18


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