Some Problems of Thalassemia in Jakarta

Main Article Content

Iskandar Wahidiyat
A.H. Markum
M. Abdulsalam
S. Muslichan

Abstract

Within 10 years (1964 - 1974) two hundred and twenty one thalassemic children were observed in the Department of Child Health, Medical School, University of Indonesia in Jakarta. They consisted of 119 cases of thalassemia major, 95 thalassemia Hb E disease, 6 Hb H disease and 1 thalassemia Hb S disease. The main treatment of thalassemia major is still blood transfusion. Splenectomy was performed on 29 children with thalassemia major and 26 cases with thalassemia Hb E disease. Splenectomy performed on cases before hypersplenism appeared, showed better results then those late cases who have already symptoms of hypersplenism. Beside the medical points of view thalassemia has also many social aspects to be considered, those of the child itself, the parents and the society or community.

Article Details

How to Cite
1.
Wahidiyat I, Markum A, Abdulsalam M, Muslichan S. Some Problems of Thalassemia in Jakarta. PI [Internet]. 13Jun.2017 [cited 3Mar.2021];18(3-4):100-. Available from: https://www.paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1467
Section
Articles
Received 2017-06-02
Accepted 2017-06-02
Published 2017-06-13

References

BETKE, K., MARTI, H.R. and SCHLICHT, I. : Estimation of small percentage of foetal hemoglobin. Nature. Lond. 184 : 1877 (1959).

DACIE, J.V. and LEWIS, S.M. : Practical hematology, 3rd. ed. (Churchil, London 1963).

HORAN, M.B. and COLEBATCH, J.H.: Relation between splenectomy and subsequent infection. Arh. Dis. Childh. 37 : 398 (1962).

KUNKEL, H:G., CEPELINI, R., MULLER-EBERHARD, U. and WOLF, J. : Observations on the minor basic hemoglobin component in blood of normal individuals and patients with thalassemia. J. clin. Invest. 36 : 1615 (1957).

LICHTMAN, H:C;; WATSON, R,J.; FELDMAN, F.; GINSBERG, V. and ROBINSON, J. : Studies on thalassemia: I. An extra corpuscular defect in thalassemia major. II. The effect of splenectomy in thalassemia major with an associated acquired hemolytic anemia. J. clin. Invest. 32 : 1229 (1953).

MOTULSKY, A.G.; CASSERD, F.; E.R; BROUN, G.O., Jr. and FINCH, C.H. : Anemia and spleen. New Engl. J. Med. 259 : 1164 (1958).

ORSINI, A. : Die thalassamien. Nouv. Presse med. 2 : 2089 (1973). Cited from: Pediatrics Zentralblatt fur die gesamte Kinderheilkunde 115 : 260 (1975).

SMITH, C.H.; ERLADSON, M:E.; STERN, G. and SCHULMAN, I. : The role of splenectomy in the management of thalassemia. Blood 15 : 197 (1960).

TAFT, L.E. and MILLER, A.G. : Thalassemia l. Pathogenesis and diagnosis. Austr. paediatr. J. 4 : 156 (1968).

WOLMAN, I.J. : Transfusion therapy as related to long-range haemoglobin levels. A progress report. Ann. N.Y. Acad. in Cooley's anemia: Growth and health Sci. 119 : 736 (1964).

WOLMAN, I.J. and ORTOLANI, M. : Some clinical features of Cooley's anemia patients as related to transfusion schedules. Ann. N.Y. Acad. Sci. 165 : 407 (1969).