Conservative Treatment of Chronic Renal Failure (CRF)

  • Richard N. Fine Division of Pediatric Nephrology UCLA Center for the Health Guenees University of California, Los Angeles
Keywords: chronic renal filure; glomerular filtration rate; GFR; nephrectomy

Abstract

The infant, child and adolescent who has irreversible impairment of renal function, regardless of the specific etiology, invariably experiences a progressive decline in glomerular filtration rate (GFR) over time. This decline in GFR can be attributed to an unremitting attack on the remaining unaffected nephrons by, the primary disease process such as in a patient with acquired immune complex disease, but the reasons for the progressive decline in GFR in patients with congenital diseases are more difficult to identify.

Currently the hypothesis attributing the decline in GFR to damage to the remaining intact nephrons resulting from hyperperfusion is receiving increasing attention. Creation of CRF in the rat model by 7/8 nephrectomy leads to a rapid decline in GFR and focal glomerulosclerosis (FGS) in the previously normal glomeruli. This lesion of FGS is presumably a result of hyperperfusion of the remaining normal nephrons in order to compensate for the reduction in functioning renal mass.

Published
2019-07-29
How to Cite
1.
Fine R. Conservative Treatment of Chronic Renal Failure (CRF). PI [Internet]. 29Jul.2019 [cited 29Mar.2024];28(9-10):214-. Available from: https://www.paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2259
Received 2019-07-29
Published 2019-07-29