Thrombospondin-1 and blood pressure in 7-8-year-old children born low birth weight and small for gestational age

  • Marlyn Malonda Department of Child Health, Sam Ratulangi University Medical School/Prof Dr. R. D. Kandou Hospital, Manado, North Sulawesi
  • Adrian Umboh Department of Child Health, Sam Ratulangi University Medical School/Prof Dr. R. D. Kandou Hospital, Manado, North Sulawesi
  • Stefanus Gunawan Department of Child Health, Sam Ratulangi University Medical School/Prof Dr. R. D. Kandou Hospital, Manado, North Sulawesi
Keywords: thrombospondin-1, blood pressure, low birth weight, small for gestational age

Abstract

Background Thrombospondin-1 (TSP-1) is associated with endothelial damage, glomerular impairment, and hypertension. Low birth weight (LBW) and small for gestational age (SGA) children have higher risk of morbidity and mortality.

Objective To assess for a possible association between TSP-1 level and blood pressure in children who were born low birth weight and small for gestational age.

Methods We conducted a cross-sectional study from March to May 2015. Inclusion criteria were children who were born LBW and SGA in 2007-2008 at Prof. Dr. R. D. Kandou General Hospital, resided in Manado, North Sulawesi, had complete medical records, and whose parents consented to their participation. Exclusion criteria were children who were in puberty, obese, had renal disease, taking medications that affect blood pressure, or who were admitted to the hospital in the 2 weeks prior to enrollment.  Data were analyzed using regression and simple correlation tests to assess for associations between TSP-1 and birth weight, as well as TSP-1 and blood pressure.

Results Subjects’ mean TSP-1 level was 257.95 ng/dL. There was a strong negative correlation between TSP-1 and birth weight (r=-0.784; P<0.0001). In addition, there were strong positive correlations between TSP-1 level and systolic blood pressure (r=0.718; P<0.0001) as well as TSP-1 and diastolic blood pressure (r=0.670; P<0.0001).

Conclusion Higher TSP-1 is associated with higher systolic and diastolic blood pressure in 7-8-year-old children who were LBW and SGA at birth. Also, TSP-1 and birth weight have a strong negative correlation.

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Published
2018-01-05
How to Cite
1.
Malonda M, Umboh A, Gunawan S. Thrombospondin-1 and blood pressure in 7-8-year-old children born low birth weight and small for gestational age. PI [Internet]. 5Jan.2018 [cited 29Mar.2024];57(5):269-3. Available from: https://www.paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1668
Received 2017-10-13
Accepted 2017-10-31
Published 2018-01-05